Amelioration of human lupus-like phenotypes in MRL/lpr mice by over expression of IL-27Rα (WSX-1)
نویسندگان
چکیده
Naonobu Sugiyama, Hitoshi Nakashima, Takeru Yoshimura , Atsushi Sadanaga, Sakiko Shimizu, Kohsuke Masutani, Takashi Igawa, Mitsuteru Akahoshi, Katsuhisa Miyake, Atsunobu Takeda, Akihiko Yoshimura, Shinjiro Hamano and Hiroki Yoshida 1. Department of Medicine and Biosystemic Science, 2. Department of Ophthalmology, 3. Department of Medicine and Clinical Science, 4. Department of Parasitology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan 5. Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan 6. Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga, 849-8501, Japan, and 7. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, School of Medicine, Fukuoka, 814-0180, Japan
منابع مشابه
Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor α (WSX-1)
OBJECTIVE In the present work, we investigate the role of interleukin (IL)27/IL27 receptor alpha (Ralpha) (WSX-1) in the development of autoimmune disorders in the MRL/lpr mouse, which is considered as an experimental model of systemic lupus erythaematosus (SLE) in humans. METHODS We generated two strains of WSX-1 transgenic mice in the MRL/lpr background with different expression levels of W...
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